How to add JS Drag-&-Drop file upload without any dependencies

/**
 * Initialize drag & drop event handling for a DOM element.
 * The DOM element does not have to be empty in order to do this.
 * @param elem The DOM element where files can be dragged & dropped
 * @param callback The callback(files) function that gets passed a list of files
 * when files are dragged and dropped.
 *
 * Basic usage example:
 *  var elem = document.getElementById('mydiv');
 *  initializeDragAndDrop(elem, function(files) {
 *      for (var i = 0; i < files.length; i++) {
 *          // Do something with files[i]...
 *          handleUploadedFile(files[i]); // Replace by your code
 *      }
 *  });
 */
function initializeDragAndDrop (elem, callback) {
    elem.addEventListener('drop', function (event) {
        _dragndrop_preventDefault(event);
        callback(event.dataTransfer.files);
    }, false);
    elem.addEventListener('dragover', _dragndrop_preventDefault, false);
    elem.addEventListener('dragdrop', _dragndrop_preventDefault, false);
    elem.addEventListener('dragenter', _dragndrop_preventDefault, false);
    elem.addEventListener('dragleave', _dragndrop_preventDefault, false);
}

/**
 * Internal utility function to prevent default
 * handling for a given event.
 */
function _dragndrop_preventDefault (event) {
    event.stopPropagation();
    event.preventDefault();
}

var elem = document.getElementById('mydiv');
initializeDragAndDrop(elem, function(files) {
    for (var i = 0; i < files.length; i++) {
        // Do something with files[i]...
        handleUploadedFile(files[i]); // Replace by your code
    }
});

$(document).ready(function() {
    initializeDragAndDrop(/* ... */);
});

// WARNING: This will replace any window.onload function
// that is currently set.
// Also, this will only fire after everything on the page
// has been loaded, which might not be the desired behaviour.
window.onload = function() {
    initializeDragAndDrop(/* ... */);
};